There is a growing push for biomedical and pharmaceutical research to transition towards three-dimensional (3D) cell culture models. Animal models can mimic human in vivo responses, but they are costly, scarce, and ethically challenging. In vitro models are cheap and easy to create, but as monolayers on stiff substrates, they poorly predict in vivo response, as they do not mimic the 3D structure of native tissue, and miss a wide array of important cell-cell and cell-matrix interactions. This has led researchers previously to choose between accuracy and throughput, but this has become a false choice with the rise of 3D cell culture technologies that can recreate complex structures that mimic native tissue in vitro. Yet, currently available technologies for 3D cell culture suffer from high cost, long fabrication time, and difficulty.
To address that unmet need for 3D cell culture systems that are robust yet rapid and easy, Nano3D Biosciences (n3D) has developed magnetic cell culture. Our technology centers around the use of NanoShuttleTM-PL, biocompatible magnetic nanoparticles, to magnetize cells so they can be easily manipulated with magnetic forces. Using this technology, users can levitate cells or rapidly print cells into tissue-like structures. The applications of this technology are wide-ranging, from biomedical research to compound screening to tissue engineering.
Our mission at n3D are to develop our magnetic cell culture technology into the industry standard for 3D cell culture